CVTree4: Composition Vector Tree Version 4

CVTree constructs whole-genome-based phylogenetic trees without sequence alignment by using a Composition Vector (CV) approach. It was first developed to infer evolutionary relatedness of microbial organisms and then successfully applied to viruses, chloroplasts, and fungi. WebCVTree4 makes comparison with taxonomy and reports tree-branch monophyleticity from domain to species. Please read the Online User's Manual for details.

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1. GH Zuo (2025) WebCVTree4: A Newly Phylogenetic and Taxonomic Study Platform of Prokaryote by Using Composition Vectors and Whole Genomes, In Submission
2. GH Zuo (2021) CVTree: A Parallel Alignment-free Phylogeny and Taxonomy Tool based on Composition Vectors of Genomes, Genomics Proteomics & Bioinformatics, 19:662-667
3. J Qi, B Wang, BL Hao (2004) Whole proteome prokaryote phylogeny without sequence alignment: a K-string composition approach, J Mol Evol, 58:1–11